Publications

• Yan, Y., K. N. Krecke, A. S. Bapat, T. Yang, M. W. Lopresti, D. G. Mashek and A. Kelekar. Phosphatase PHLPP2 regulates the cellular response to metabolic stress through AMPK. 2021. Cell Death and Disease (in press).                                                                                                                          
• Hanse, E. A., C. Ruan, M. Kachman, D. Wang, X. H. Lowman, and A. Kelekar. Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer. Oncogene advance online publication http://www.nature.com/doifinder/10.1038/onc.2017.36

 

• Yan, Y., Hanse, E.A., Stedman, K., Benson, J.M., Lowman, X.H., Subramanian, S., and Kelekar, A. Transcription factor C/EBP- induces tumor suppressor phosphatase PHLPP2 through repression of the miR-17~92 cluster in differentiating AML cells. Cell Death and Differentiation. Epub ahead of print. doi:10.1038/cdd.2016.1. PMID26868909 

 

• Olenchock B. A., J. Moslehi, A. H. Baik, S. M. Davidson, J. Williams, W. J. Gibson, K. A. Pierce, C. Miller, E. A. Hanse, A. Kelekar, L. B. Sullivan, A. Wagers, C. B. Clish, M. G. Vander Heiden, William G. Kaelin, Jr. Inhibition of the EglN1 Oxygen Sensor and Rerouting of ?-Ketoglutarate are Sufficient for Remote Ischemic Protection. Cell,2016. 164:884-895. http://dx.doi.org/10.1016/j.cell.2016.02.006

 

• Karim, C. B., L. M. Espinoza-Fonseca, J. Zachary, E. A. Hanse, J. S. Gaynes, D. D. Thomas and A. Kelekar. Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation. Scientific Reports, 2015. 5: 14557. PMC4585961

 

• Espinoza-Fonseca, L. M. and A. Kelekar. High-resolution structural characterization of Noxa, an intrinsically disordered protein by microsecond molecular dynamics simulations. Molecular BioSystems. 2015. 11: 1850-1856. PMC4470721

 

• Das, S. G., D. L. Hermanson, N. Bleeker, X. Lowman, Y. Li, A. Kelekar, C. Xing. 2013. Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) – a novel scaffold that re-sensitizes multidrug resistant leukemia cells to chemotherapy. ACS Chemical Biology 8 (2): 327-335.

 

• Sanchez, C., P. Perfornis, A. Oskowitz, A. Boonjindasup, D. Cai. S. Dhule. B. Rowan, A. Kelekar, D. Krause, and R. Pochampally. Activation of autophagy in mesenchymal stem cells provides tumor stromal support.Carcinogenesis. 2011 Jul;32(7):964-72. doi: 10.1093/carcin/bgr029.

 

• Lowman X. H., M. A. McDonnell, O. A. Odumade, A. Kosloske, C. Jenness, C. B. Karim, R. Jemmerson, and A. Kelekar . The Proapoptotic Function of Noxa in Human Leukemia Cells Is Regulated by the Kinase Cdk5 and by Glucose.Molecular Cell, 2010. 40 (5): 823-833.

 

• Preview to Lowman et al article: Gimenez-Cassina, A and N.N. Danial. Noxa: a Sweet Twist to Survival and more.Molecular Cell, 2010. 40 (5): 687-688.

 

• Codina, R., A. Vanasse, A. Kelekar, V. Vezys and R. Jemmerson. 2010. Cytochrome c-Induced Lymphocyte Death from the Outside In: Inhibition by Serum Leucine-Rich Alpha-2-Glycoprotein-1.Apoptosis, 15: 139-152.

 

• Bui Nguyen, T.M., I.V. Subramanian, X. Xue, G. Ghosh, P. Nguyen, A. Kelekar, and S. Ramakrishnan. 2009. Endostatin induces autophagy in endothelial cells by modulating Beclin-1 and b-catenin levels. Journal of Cellular and Molecular Medicine, 13:3687-3698.

 

• Kelekar, A. 2008. Edited and Introduced the Review Series Autophagy in Higher Eukaryotes- A matter of survival or death. Autophagy, 4 (5): 555 - 556.

 

• McDonnell, M. A., M. J. Abedin, M. Melendez, T. Platikanova, J. R. Ecklund, K. Ahmed, and A. Kelekar. 2008. Phosphorylation of Caspase-9 by Casein Kinase 2 regulates its cleavage by Caspase-8. Journal of Biological Chemistry 283 (29), 20149-20158 (E-pub ahead of print), May 8, 2008).

 

• Klionsky, D. et al. 2008. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy, 4(2):151-175.

 

• Ramakrishnan. S., T. Bui Nguyen, I. V Subramanian and A. Kelekar. 2007. Autophagy and Angiogenesis - an Addendum. Autophagy. 3:512-515.

 

• Zhao, Y.B., J. Altman, J.L. Coloff, C.E. Herman, S.R. Jacobs, H.L. Wieman, J.A. Wofford, L.N. Dimascio, O. Ilkayeva, A. Kelekar, T. Reya and J.C. Rathmell. 2007. GSK-3 alpha/beta Mediate a Glucose-Sensitive Anti-Apoptotic Signaling Pathway to Stabilize Mcl-1. Mol. Cell. Biol. 27:4328-4339.

 

• Abedin, M. J, D. Wang, M. A. McDonnell, U. Lehmann, and A. Kelekar. 2007. Autophagy delays apoptotic death in breast cancer cells following DNA damage. Cell Death and Differentiation. 14:500-510; advance online publication, September 22, 2006; di:10.1038/sj.cdd.4402039.

 

• Bui-Nguyen, T., I. V Subramanian, A. Kelekar and S. Ramakrishnan. 2007. Angiogenesis Inhibitor, Kringle 5 of human plasminogen, induces both autophagy and apoptotic death in endothelial cells. Blood 109(11):4793-802.

 

• Kelekar, A. 2005. Autophagy in Cell Injury: Mechanisms, Responses and Repair, Annals of the New York Academy of Sciences. 2006. 1066:1363.015.

 

• Goldstein, J. C., C. Muñoz-Pinedo, J-E. Ricci, S. R. Adams, A. Kelekar, M. Schuler, R. Y. Tsien, and D. R. Green. 2005. Cytochrome c is released in a single step during apoptosis. Cell Death and Differentiation 12, 453-462.

 

• Wang, D., M.A. McDonnell and A. Kelekar. 2005. Multi-probe RPA template sets to study RNA modulation and transcriptional control of BH3-only members of the Bcl-2 family. Cancer Detection and Prevention, 29:189-200.

 

• Ke, H., J. Pei, Z. Ni, H. Xia, H. Qi, T. Woods, A. Kelekar, and W. Tao. 2004. Putative tumor suppressor LATS2 induces apoptosis through down regulation of Bcl-2 and Bcl-xL. Experimental Cell Research, 298:329-338. Abstract

 

• Vallera D. A, N. Jin, Y. Shu, A. Panoskaltsis-Mortari, A. Kelekar, and W. Chen. 2003. Retroviral immunotoxin gene therapy of leukemia in mice using leukemia-specific T cells transduced with an IL-3/Bax hybrid gene. Human Gene Therapy 4:1787-98.

 

• McDonnell, M. A., D. Wang, S M. Khan, M. G. Vander Heiden, and A. Kelekar. 2003. Caspase-9 is activated in a cytochrome c-independent manner early during TNFa-induced apoptosis in murine cells. Cell Death and Differentiation. 10: 1005-1015.

 

• Kelekar, A. and C. B. Thompson. BH domains. The Encyclopedia of Molecular Medicine 2001. John Wiley & Sons, New York., pages 353-357.

 

• Kelekar, A. and C. B. Thompson. Bcl-2 proteins. The Encyclopedia of Molecular Medicine 2001, John Wiley & Sons, New York, pages 328-333.

 

• Kaspar A. A., S. Okada, J. Kumar, F. R. Poulain, K. A. Drouvalakis, A. Kelekar, D. A. Hanson, R. M. Kluck, Y. Hitoshi, D. E. Johnson, C. J. Froelich, C. B. Thompson, D. D. Newmeyer, A. Anel, C. Clayberger, and A. M. Krensky. 2001. A distinct pathway of cell-mediated apoptosis initiated by granulysin. J Immunol. 167: 350-356.

 

• Kelekar, A., B. S. Chang, M. H. Harris, J. E. Harlan, S. W. Fesik and C. B. Thompson.1999. The BH3 domain of Bcl-xS is required for the inhibition of the anti-apoptotic function of Bcl-xL. Mol. Cell. Biol. 19: 6673-6681.

 

• Pena, J. C., A. Kelekar, E. V. Fuchs and C. B. Thompson. 1999. Manipulation of outer root sheath survival perturbs the hair growth cycle. The EMBO Journal 18: 3596-3603.

 

• Minn, A. J., C. S. Kettlun, H. Liang, A. Kelekar, M. G. Vander Heiden, B. S. Chang, S. W. Fesik, M. Fill and C. B. Thompson. 1999. Bcl-xL regulates apoptosis by heterodimerization-dependent and heterodimerization-independent mechanisms. The EMBO Journal 18: 632-643.

 

• Kelekar, A. and C.B. Thompson. 1998. Bcl-2 Homology Domains: The role of the BH3 domain in apoptosis. Trends in Cell Biology 8: 324-330.

 

• Kelekar, A., B. S. Chang, J. E. Harlan, S. W. Fesik and C. B. Thompson. 1997. Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-xL. Mol. Cell. Biol. 17: 7040-7046.